In 2022, a research team from Manchester conducted a comparative clinical study where different concentrations of retinol serum were tested on participants with mature skin type. The concentrations tested were 0.1%, 0.3% and 0.5% retinol. In the study, they found that higher concentration does not always produce better results.
The participants who used the 0.5% retinol serum suffered significantly more side effects compared to those who used the 0.3% and 0.1%. After 8 to 12 weeks, the study clearly showed that the test participants who used the 0.3% and 0.5% concentrations showed a greater side effect profile, with the side effects of 0.5% retinol being most prominent.
"AHA Acids: Higher Concentrations Affect the Skin's Microbiome Negatively - New Study Shows"
In a study by research groups from Serbia and Germany, the application of cream with 2% glycolic acid and 10% glycolic acid was compared. It was then seen that the higher concentration of glycolic acid of 10% killed an important skin bacterium, S Epidermidis, which leads to an imbalanced microbiome.
Skinome's fresh skin care and cold storage
With Skinome's products, we guarantee that you get a safe product that takes into account the recommended dosage range and that our active ingredients retain their effect throughout the shelf life. Therefore, we make sure to immediately cool our products after production and recommend that you, as a customer, store the products in your refrigerator for maximum effect. This ensures that your skin receives the concentration of active ingredients that gives the best results and leads to healthy skin.
References
Milica Lukic, Mila Filipovic, Nevena Pajic, Dominique Lunter, Dragana Bozic, SS (2021). Formulation of topical acidic products and acidification of the skin - Contribution of glycolic acid. Int J Cosmet Sci .
Kieran T Mellody 1 2, Eleanor J Bradley 3, Bezaleel Mambwe 1, Lindsay F Cotterell 1 2, Orsolya Kiss 1 2, Poonam Halai 1 2, Zeena Loftus 3, Mike Bell 3, Tamara W Griffiths 1 2, Christopher EM Griffiths 1 2 4, REBW 1 2 4. (2022). Multifaceted amelioration of cutaneous photoaging by (0.3%) retinol. Int J Cosmet Sci.
Malwina Zasada, Elzbieta Budzisz, AE-P. (2020). A Clinical Anti-Ageing Comparative Study of 0.3 and 0.5% Retinol Serums: A Clinically Controlled Trial. Skin Pharmacol Physiol .
